Question 1

What is ISTamet XR 500 Tablet?

Accepted Answer

ISTamet XR 500 Tablet is a combination of two medicines: sitagliptin and metformin. This medicine is used in the treatment of type 2 diabetes mellitus. It improves blood glucose levels in adults when taken along with a proper diet and regular exercise. Metformin lowers glucose production in the liver and improves insulin sensitivity. Sitagliptin inhibits the enzyme DPP4 and increases insulin release from the pancreas. This combination is not indicated for patients below 18 years of age.

Question 2

What are the possible side effects of ISTamet XR 500 Tablet?

Accepted Answer

The use of ISTamet XR 500 Tablet is associated with common side effects like diarrhea, headache, and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to vitamin B12 deficiency.

Question 3

Are there any specific conditions in which ISTamet XR 500 Tablet should not be taken?

Accepted Answer

The use of ISTamet XR 500 Tablet should be avoided in patients with known allergies to any of the components or excipients of this medicine. The use of this medicine should be avoided in patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis, or diabetic ketoacidosis.

Question 4

Is it safe to take alcohol while I am taking ISTamet XR 500 Tablet?

Accepted Answer

No, it is not safe to consume alcohol along with ISTamet XR 500 Tablet, as it can increase the chances of lactic acidosis.

Question 5

Can the use of ISTamet XR 500 Tablet lead to lactic acidosis?

Accepted Answer

Yes, the use of ISTamet XR 500 Tablet can lead to lactic acidosis. It is a medical emergency caused by the increased levels of lactic acid in the blood. It is also known as MALA (metformin-associated lactic acidosis). It is a rare side effect associated with the use of metformin. Therefore, it is avoided in patients with underlying kidney disease, elderly patients, or those who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, a feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain, or a slow heart rate. If you have these symptoms, stop taking sitagliptin + metformin and immediately consult your doctor.

Question 6

Can the use of ISTamet XR 500 Tablet lead to vitamin B12 deficiency?

Accepted Answer

Yes, using ISTamet XR 500 Tablet can cause vitamin B12 deficiency in the long term. It interferes with the absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems, as a result of which the patient can feel a tingling sensation and numbness in hands and feet, weakness, urinary problems, a change in mental status, and difficulty maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside sources at least once every year.

Question 7

What are the instructions for storage and disposal of ISTamet XR 500 Tablet?

Accepted Answer

Keep this medicine tightly closed in the container or pack it came in. Store it according to the instructions on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, or other people.

ISTAMET XR 500 TABLET

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